With our services, we assist the pharmaceutical, biotech, and academic communities from early preclinical research, including in vivo models, through large-scale, late-stage clinical trial programs for vaccines, monoclonal antibodies, and antivirals. In our BSL2 and BSL3 containment laboratories, we provide fully validated assays targeting a wide range of viruses, as well as preclinical models and a comprehensive portfolio of virological, molecular, and immunological assays. In addition, our full suite of global logistics services supports sample processing, storage, and transport.

Our in-house R&D capabilities enable the development and validation of new assays, the optimization of existing methods, and the implementation of client-specific assays. Highly customized solutions include innovative platforms such as the Virospot™ assay, designed for viral detection and phenotypic characterization, particularly of influenza viruses, in phase 2 and phase 3 clinical trials of novel antiviral compounds. This platform integrates classical virus culture techniques with automated, highly sensitive detection of immunostained virus-infected cells and is now applicable to a broad range of viral targets.

Assays can also be transferred to partner laboratories in regions where the export of clinical samples is restricted.

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Our Services

Virological Assays

  • We provide phenotyping of virus in specimens or after virus culture.
  • We have multiple high-throughput plaque assays available, including high-throughput focus reduction assays with a 96-well format.
  • Our viral assays include virus titration techniques, virus neutralization evaluation, virus inhibition analysis, ELISA and ELISpot/Fluoro spot assays, etc.
  • Assays available for influenza (including HPAIV), RSV, hMPV, PIV, CMV, dengue and more.
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BSL3

Preclinical models

  • We use the wild-type virus in our BSL2 and BSL3 facilities to provide confirmed animal models for studying a variety of viral targets such as  influenza virus, SARS-CoV-2, MERS, RSV, HSV and others.
  • We provide in vitro assays as well as in vivo studies with a variety of animal models.
  • We offer proof of concept studies for vaccines and antiviral components (PK studies, immunogenicity and efficacy testing).

Our experienced preclinical team offers you tailor-made advice for your project.

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Global Logistics Services

Global Logistics Services

  • Preparation of virology sampling kits.
  • On-site sample handling instruction and courier transport.
  • Sample tracking and tracing (e.g., guaranteeing temperature-controlled supply chain and online-sample timelines).
  • Management of sample processing labs.
  • Network of 41 processing labs.
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Molecular Assays

  • We conduct quantitative PCR for viruses and bacteria.
  • We can provide multiplex (q)PCR and genotyping assays.
  • We have experience with the development of single and multiplex ddPCR assays.
  • Extensive experience in Next Generation Sequencing (NGS) and long-read sequencing.
  • Validated NGS pipelines to support CDISC-compliant data reporting by a dedicated BIO-IT team.
  • Virology: (dd)PCR and NGS assays for Hepatitis B, C and Delta, Human Papillomavirus, RSV, hMPV, influenza,  SARS-CoV-2, MERS, CMV, EBV.
  • Bacteriology: qPCRs, 16S rRNA, whole genome sequencing, metagenomics.

Reach out to our experts and see how we can help advance your clinical trial. You can also find out more about our vaccine lab services.